Hotels near Mayo Clinic Rochester

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If you visit Rochester, be sure to see Mayo Clinic Rochester, which is a popular spot in Rochester. There are many hotel options near Mayo Clinic Rochester to suit your preferences. You can find many budget hotels near Mayo Clinic Rochester, or places farther away at various price points. Below are the closest hotels to Mayo Clinic Rochester in Rochester, United States of America.

Hotels near Mayo Clinic Rochester

12 nearby hotels 2 Oct 2026 – 3 Oct 2026 · 2 guests

  • Rochester Marriott Mayo Clinic Area

    Rochester Marriott Mayo Clinic Area

    ★★★ (2 reviews) 6.5

    123 m from Mayo Clinic Rochester

    🍳 Breakfast included
    $249 per night
  • Hilton Garden Inn Rochester Downtown

    Hilton Garden Inn Rochester Downtown

    ★★★ (11 reviews) 8.9

    129 m from Mayo Clinic Rochester

    📶 Free Wi-Fi 🍳 Breakfast included
    $122 per night
  • Hotel Indigo Rochester Mayo Clinic Area By IHG

    Hotel Indigo Rochester Mayo Clinic Area By IHG

    ★★★ (21 reviews) 8.8

    157 m from Mayo Clinic Rochester

    📶 Free Wi-Fi 🍳 Breakfast included
    $112 per night
  • Kahler Grand Hotel

    Kahler Grand Hotel

    ★★★ (328 reviews) 8

    240 m from Mayo Clinic Rochester

    📶 Free Wi-Fi
    $148 per night
  • Hilton Rochester Mayo Clinic Area

    Hilton Rochester Mayo Clinic Area

    ★★★★ (15 reviews) 8.6

    264 m from Mayo Clinic Rochester

    📶 Free Wi-Fi 🍳 Breakfast included
    $188 per night
  • Kahler Inn and Suites

    Kahler Inn and Suites

    ★★★ (562 reviews) 8.1

    373 m from Mayo Clinic Rochester

    📶 Free Wi-Fi 🍳 Breakfast included
    $184 per night
  • Centerstone Plaza Hotel Soldiers Field

    Centerstone Plaza Hotel Soldiers Field

    ★★★ (57 reviews) 8.8

    553 m from Mayo Clinic Rochester

    📶 Free Wi-Fi 🍳 Breakfast included
    $114 per night
  • SpringHill Suites by Marriott Rochester Mayo Clinic Area/Saint Marys

    SpringHill Suites by Marriott Rochester Mayo Clinic Area/Saint Marys

    ★★★ (5 reviews) 8.1

    1.2 km from Mayo Clinic Rochester

    📶 Free Wi-Fi 🍳 Breakfast included
    $116 per night

  • Aspen Select

    ★★ (112 reviews) 8.8

    1.4 km from Mayo Clinic Rochester

    📶 Free Wi-Fi 🍳 Breakfast included
    $98 per night
  • Baymont by Wyndham Rochester Mayo Clinic Area

    Baymont by Wyndham Rochester Mayo Clinic Area

    ★★ (84 reviews) 7.8

    1.8 km from Mayo Clinic Rochester

    📶 Free Wi-Fi 🍳 Breakfast included
    $64 per night
  • Holiday Inn Express and Suites Rochester West-Medical Center By IHG

    Holiday Inn Express and Suites Rochester West-Medical Center By IHG

    ★★ (4 reviews) 8.9

    1.8 km from Mayo Clinic Rochester

    📶 Free Wi-Fi 🍳 Breakfast included
    $110 per night
  • Fairfield by Marriott Inn & Suites Rochester Mayo Clinic Area/Saint Marys

    Fairfield by Marriott Inn & Suites Rochester Mayo Clinic Area/Saint Marys

    ★★ (101 reviews) 9.4

    2.0 km from Mayo Clinic Rochester

    🍳 Breakfast included
    $139 per night